Metabolic health
Weight, insulin resistance and metabolic syndrome
For excess weight, the approach is cause-focused. Insulin resistance, leptin resistance and metabolic status are investigated; where needed, GLP-1 therapy is given only under medical supervision.
Insulin resistance can exist despite normal sugar
Normal fasting sugar does not mean a healthy metabolism. Insulin resistance is calculated with the HOMA-IR formula: (fasting glucose × fasting insulin) / 405. A result above 2.5 indicates resistance.
Signs of insulin resistance
- Frequent hunger
- Trembling when meals are delayed
- Acanthosis nigricans (darkening in skin folds)
- Acne
- Sleep disturbance
- Difficulty losing weight
Work-up & treatment
Weight & metabolic syndrome services
Which tests are done?
Fasting insulin and glucose, HOMA-IR, OGTT and leptin resistance — for a full assessment of metabolic status.
How is weight loss planned?
The approach is cause-focused — not just calories, but the hormonal/metabolic cause is identified. The plan is individual.
When is GLP-1 used?
Injectable therapy is prescribed only to selected patients, after blood tests and ultrasound, under medical supervision.
Related conditions
- Overweight and obesity
- Metabolic syndrome
- Leptin resistance
- Acanthosis nigricans
- Striae — search for endocrine causes
- Cause-focused weight loss
What you should know
Accurate information
Acanthosis nigricans is a sign of insulin resistance
Darkening and thickening of the skin on the neck, armpits and groin is a skin sign of insulin resistance. Without addressing the cause, creams give no result.
Weight-loss injections are dangerous without medical supervision
GLP-1 analogues should be prescribed after examination and tests, not from advertising or a friend's advice. A dosing error can cause serious complications; after stopping, a plan against weight regain is essential.
FAQ
Frequently asked questions
If I have insulin resistance, will it turn into diabetes?
Not necessarily. Insulin resistance is the most important risk factor for type 2 diabetes, but with the right intervention full diabetes can be prevented. Physical activity, proper nutrition and weight loss are the main measures.
Are weight-loss injections (GLP-1) suitable for everyone?
No. These injections are prescribed after certain tests, on individual indication. The dose, duration and post-treatment plan must be set by the doctor. Self-use can lead to serious complications.
Is acanthosis nigricans only a cosmetic problem?
No. Darkening and thickening of the skin on the neck, armpits and groin is a sign of insulin resistance and type 2 diabetes. Without addressing the cause, creams do not help.
How is insulin resistance calculated?
By the HOMA-IR formula: (fasting glucose × fasting insulin) / 405. A result above 2.5 indicates insulin resistance. Frequent hunger, trembling when meals are delayed, acanthosis nigricans and sleep problems can be signals.
Book a metabolic assessment
If you cannot lose weight or suspect insulin resistance, the cause can be identified with the right tests.